In preparing for their experiments knew Sterns group to a protein called Nf1 neurofibromin.

In preparing for their experiments knew Stern’s group to a protein called Nf1 neurofibromin, the the encodes a second protein called Ras, which is known to promote nerve cell growth inhibition. They also knew that a third protein called PI3K was recently reported that, in mice, the defective Nf1 genes had become hyperactivated, and they knew that PI3K activity of a fourth protein called Akt requires to perform its tasks.

Stern used research group fruit flies for several reasons. The insect genome has been sequenced, it only takes two weeks new generation of new generation of fruit flies;. And scientists know which fruit flies are genes similar connected to the human genes with neurofibromatosis.The checklist is designed the punctual the timely case of of trastuzumab in breast cancer. The checklist is an instrument for the systematic considering all factors. HTA Spend more for decision problem hope increases impact of the HTA and a better better policy making.

The checklist can assist on frame HTAs can, and adapt existing HTAs carry so they applicable to improve.. Do not give increasingly, however, the real world. Therefore, they are not always be on a decision Problem with this, and no to meet the needs of decision makers. – A recently conducted trial, Bridging to hear and determine: A checklist to health technology assessment for resource allocation judgments context, published in the Value in Health, ratings question that may interfere the applicability of HTAs for reimbursement decisions.