Consequently, the team mapped the distribution of CD44 at the lymphocyte cell surface in liquid by correlative immune-fluorescence optical and immuno-electron microscopy using a combined fluorescence and atmospheric scanning electron microscope. Once CD44 cell surface area labelling was confirmed with the pictures from the Neo sCMOS detector, atmospheric SEM revealed the microvilli on the cell surface area with the localisation of label on the microvilli. Dual labelling was utilized using an anti-CD44 monoclonal antibody and a secondary antibody conjugated with Alexa Fluor 488 and 1.4 nm charged Nanogold particles, says Toshiyuki Murai, lead author of the paper.The Task Force recommends that males between the age range of 45 and 79 should use aspirin to lessen their risk for heart attacks when the huge benefits outweigh the harms for potential gastrointestinal bleeding. Ladies between the ages of 55 and 79 should make use of aspirin to lessen their risk for ischemic stroke when the benefits outweigh the harms for potential gastrointestinal bleeding. Ischemic strokes take place due to an obstruction within a blood vessel supplying blood to the brain and are potentially avoided by aspirin use. The risk of gastrointestinal bleeding with and without aspirin make use of raises with age group and is doubly high in males as in women.