The inclusion and exclusion criteria for the AEGIS study are comparable to those in a previous phase 3 trials, Alexion’s Soliris as a treatment for PNH, the SHEPHERD study uses. SHEPHERD examined the safety and efficacy of eculizumab in a broad and diverse population of patients with PNH, including enrollment of patients with minimal transfusion requirements and / or evidence of thrombocytopenia. on the SHEPHERD study and the TRIUMPH Phase 3 study, Soliris was approved as the first treatment for patients with PNH by the U.S. Food and Drug Administration in March 2007 and by the European Commission in June 2007.
PNH is a rare acquired genetic blood disorder hemolysis hemolysis, destroying destroyed red blood cells by complement, a component of the body’s immune system. The primary endpoint the study is the reduction of hemolysis from baseline. The study will also measure the effect of Soliris on other clinical manifestations of PNH, – blood transfusion requirements, thrombosis , and kidney function. Patient’s overall quality of life, including fatigue , will also be evaluated.– In addition, the hindrance information campaigns quoted frequently as a useful tool in employment of people with employment of people with education training would be addressing and to correct misunderstanding such concern that people with disabilities the appropriate competencies to be effective lack in their workplaces jobs are less productive, and the risk of accidents, the researchers said. – Preconceived views on the kind of work that the disabled with disabilities and as the workers with a disability is a huge challenge, also under the companies which active people recruiting disabled Build one barrier free cheap and cheap and.